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The Los Angeles Angels and Taylor Ward hit the field against Jeremy Pena and the Houston Astros on Sunday, in the second game of a three-game series at Angel Stadium. The Astros have been listed as -143 moneyline favorites in this matchup with the Angels (+121). Houston (-1.5) is the favorite on the run line. A 9-run over/under is set in the matchup.

Here is everything you need from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Angels Game Information & Odds

  • When: Sunday, September 28, 2025 at 3:07 p.m. ET
  • Where: Angel Stadium in Anaheim, California
  • How to watch on TV: FDSW and SCHN
  • Score Prediction: Astros 7, Angels 6
  • Total Prediction: Over 9 runs
  • Win Probabilities: Astros 50%, Angels 50%
  • The Astros have won 53, or 51.5%, of the 103 games they’ve played as favorites this season.
  • Houston is 22-19 this season when entering a game favored by -143 or more on the moneyline.
  • The sportsbooks’ moneyline implies a 58.8% chance of a victory for the Astros.
  • The Angels have been chosen as underdogs in 121 games this year and have walked away with the win 53 times (43.8%) in those games.
  • This season, Los Angeles has come away with a win 33 times in 77 chances when named as an underdog of at least +121 or worse on the moneyline.
  • Sportsbooks have implied with the moneyline set for this matchup that the Angels have a 45.2% chance of pulling out a win.
  • The Astros were favored on the moneyline in six of their last 10 games, and they finished 2-4 in those matchups.
  • Over their last 10 outings — all had a set run total — the Astros and their opponents combined to hit the over on the total five times.
  • The Astros’ ATS record is 4-6-0 over their past 10 games.
  • Jose Altuve has launched a team-best 26 home runs.
  • Altuve ranks 42nd in homers and 60th in RBI among all hitters in MLB.
  • Pena has a club-high .304 batting average.
  • Pena ranks 111th in homers and 117th in RBI among all hitters in the majors.
  • Yainer Diaz has 25 doubles, a triple, 19 home runs and 20 walks while hitting .255.
  • Carlos Correa is hitting .276 with 29 doubles, 13 home runs and 45 walks.
  • Correa brings a three-game streak with at least one hit into this one. In his last five games he is batting .294 with two doubles, four walks and two RBIs.
  • In eight games over the last 10 matchups when set as underdogs by oddsmakers, the Angels had a record of 2-6.
  • In their last 10 games with a total, the Angels and their opponents have combined to hit the over five times.
  • The Angels have three wins against the spread in their last 10 chances.
  • Ward has driven in the most runs for the Angels with 103 runs batted in.
  • Ward is 10th in home runs and 11th in RBI among all hitters in MLB.
  • Nolan Schanuel’s .264 batting average leads his team.
  • Schanuel is 175th among all hitters in the big leagues in home runs, and 153rd in RBI.
  • Jo Adell leads the Angels with 37 long balls.
  • Mike Trout is batting .230 with 14 doubles, a triple, 25 home runs and 86 walks.
  • Echa un vistazo a los mejores aspectos destacados entre los Astros de Houston y el atletismo.

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