• Ashkan, K., Rogers, P., Bergman, H. & Ughratdar, I. Insights into the mechanisms of deep brain stimulation. Nat. Rev. Neurol. 13, 548–554 (2017).

    Article 
    PubMed 

    Google Scholar 

  • McGregor, M. M. & Nelson, A. B. Circuit mechanisms of Parkinson’s disease. Neuron 101, 1042–1056 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Deuschl, G. et al. A randomized trial of deep brain stimulation for Parkinson’s disease. N. Engl. J. Med. 355, 896–908 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Follett, K. A. et al. Pallidal versus subthalamic deep brain stimulation for Parkinson’s disease. N. Engl. J. Med. 362, 2077–2091 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Odekerken, V. J. J. et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial. Lancet Neurol. 12, 37–44 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Pozzi, N. G. & Isaias, I. U. in Handbook of Clinical Neurology 1st edn, Vol. 184 (eds Quartarone A., Ghilardi M.F. & Boller F.) 273–284 (Elsevier B.V., 2022).

  • Kühn, A. A., Kupsch, A., Schneider, G. H. & Brown, P. Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson’s disease. Eur. J. Neurosci. 23, 1956–1960 (2006).

    Article 
    PubMed 

    Google Scholar 

  • Neumann, W. J. et al. Subthalamic synchronized oscillatory activity correlates with motor impairment in patients with Parkinson’s disease. Mov. Disord. 31, 1748–1751 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lofredi, R. et al. Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients. npj Parkinsons Dis. 9, 1–9 (2023).

    Article 

    Google Scholar 

  • Little, S. & Brown, P. Debugging adaptive deep brain stimulation for Parkinson’s disease. Mov. Disord. 35, 555–561 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Little, S. et al. Adaptive deep brain stimulation in advanced Parkinson disease. Ann. Neurol. 74, 449–457 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Little, S. et al. Bilateral adaptive deep brain stimulation is effective in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry 87, 717–721 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Tinkhauser, G. et al. The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson’s disease. Brain 140, 1053–1067 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • He, S. et al. Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson’s disease. Brain 146, 5015–5030 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Rosa, M. et al. Adaptive deep brain stimulation controls levodopa-induced side effects in Parkinsonian patients. Mov. Disord. 32, 628–629 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Arlotti, M. et al. Eight-hours adaptive deep brain stimulation in patients with Parkinson disease. Neurology 90, e971–e976 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Velisar, A. et al. Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients. Brain Stimul. 12, 868–876 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Gilron, R. et al. Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease. Nat. Biotechnol. 39, 1078–1085 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Oehrn, C. R. et al. Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson’s disease: a blinded randomized feasibility trial. Nat. Med. 30, 3345–3356 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kühn, A. A. et al. Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. Brain 127, 735–746 (2004).

    Article 
    PubMed 

    Google Scholar 

  • Eisinger, R. S. et al. Parkinsonian beta dynamics during rest and movement in the dorsal pallidum and subthalamic nucleus. J. Neurosci. 40, 2859–2867 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Johnson, L. A. et al. Closed-loop deep brain stimulation effects on Parkinsonian motor symptoms in a non-human primate—is beta enough? Brain Stimul. 9, 892–896 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Iturrate, I. et al. Beta-driven closed-loop deep brain stimulation can compromise human motor behavior in Parkinson’s disease. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/696385v1.abstract (2019).

  • Bologna, M., Paparella, G., Fasano, A., Hallett, M. & Berardelli, A. Evolving concepts on bradykinesia. Brain 143, 727–750 (2020).

    Article 
    PubMed 

    Google Scholar 

  • Chevalier, G. & Deniau, J. M. Disinhibition as a basic process in the expression of striatal functions. Trends Neurosci. 13, 277–280 (1990).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ivry, R. B. & Spencer, R. M. C. The neural representation of time. Curr. Opin. Neurobiol. 14, 225–232 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Klaus, A., Alves Da Silva, J. & Costa, R. M. What, if, and when to move: basal ganglia circuits and self-paced action initiation. Annu. Rev. Neurosci. 42, 459–483 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wichmann, T. & DeLong, M. R. Deep brain stimulation for movement disorders of basal ganglia origin: restoring function or functionality? Neurotherapeutics 13, 264–283 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Turner, R. S. & Desmurget, M. Basal ganglia contributions to motor control: a vigorous tutor. Curr. Opin. Neurobiol. 20, 704–716 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Darbin, O. et al. Subthalamic nucleus deep brain stimulation driven by primary motor cortex γ2 activity in parkinsonian monkeys. Sci. Rep. 12, 1–16 (2022).

    Article 

    Google Scholar 

  • Ferleger, B. I. et al. Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients. J. Neural Eng. 17, 056026 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Herron, J. A. et al. Chronic electrocorticography for sensing movement intention and closed-loop deep brain stimulation with wearable sensors in an essential tremor patient. J. Neurosurg. 127, 580–587 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Opri, E. et al. Chronic embedded cortico-thalamic closed-loop deep brain stimulation for the treatment of essential tremor. Sci. Transl. Med. 12, eaay7680 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • He, S. et al. Closed-loop deep brain stimulation for essential tremor based on thalamic local field potentials. Mov. Disord. 36, 863–873 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sellers, K. K. et al. Analysis-rcs-data: open-source toolbox for the ingestion, time-alignment, and visualization of sense and stimulation data from the Medtronic Summit RC+S system. Front. Hum. Neurosci. 15, 1–14 (2021).

    Article 

    Google Scholar 

  • Strandquist, G. et al. Bringing the clinic home: an at-home multi-modal data collection ecosystem to support adaptive deep brain stimulation. J. Vis. Exp. 197, e65305 (2023).

    Google Scholar 

  • Buzsáki, G. & Draguhn, A. Neuronal oscillations in cortical networks. Science 304, 1926–1929 (2004).

    Article 
    PubMed 

    Google Scholar 

  • Maciel, R., Zúñiga-Ramírez, C., Munhoz, R. P., Zurowski, M. & Fasano, A. Functional dyskinesias following subthalamic nucleus deep brain stimulation in Parkinson’s disease: a report of three cases. Mov. Disord. Clin. Pract. 8, 114–117 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Baizabal-Carvallo, J. F. & Jankovic, J. Movement disorders induced by deep brain stimulation. Parkinsonism Relat. Disord. 25, 1–9 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Rodríguez-Molinero, A. et al. Estimating dyskinesia severity in Parkinson’s disease by using a waist-worn sensor: concurrent validity study. Sci. Rep. 9, 1–7 (2019).

    Article 

    Google Scholar 

  • Dai, H., Zhang, P. & Lueth, T. C. Quantitative assessment of Parkinsonian tremor based on an inertial measurement unit. Sensors 15, 25055–25071 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Holt, A. B., Wilson, D., Shinn, M., Moehlis, J. & Netoff, T. I. Phasic burst stimulation: a closed-loop approach to tuning deep brain stimulation parameters for Parkinson’s disease. PLoS Comput. Biol. 12, e1005011 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Grado, L. L., Johnson, M. D. & Netoff, T. I. Bayesian adaptive dual control of deep brain stimulation in a computational model of Parkinson’s disease. PLoS Comput. Biol. 14, e1006606 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Popovych, O. V. & Tass, P. A. Adaptive delivery of continuous and delayed feedback deep brain stimulation—a computational study. Sci. Rep. 9, 10585 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Swann, N. C. et al. Adaptive deep brain stimulation for Parkinson’s disease using motor cortex sensing. J. Neural Eng. 15, e15–e16 (2018).

    Article 

    Google Scholar 

  • Gilron, R. et al. Sleep-aware adaptive deep brain stimulation control: chronic use at home with dual independent linear discriminate detectors. Front. Neurosci. 15, 732499 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Smyth, C. et al. Adaptive deep brain stimulation for sleep stage targeting in Parkinson’s disease. Brain Stimul. 16, 1292–1296 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Anjum, M. F. et al. Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson’s disease. Nat. Commun. 15, 1793 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kim, H. J., Jeon, B. S. & Paek, S. H. Non-motor symptoms and subthalamic deep brain stimulation in Parkinson’s disease. J. Mov. Disord. 8, 83–91 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kurtis, M. M., Rajah, T., Delgado, L. F. & Dafsari, H. S. The effect of deep brain stimulation on the non-motor symptoms of Parkinson’s disease: a critical review of the current evidence. npj Parkinsons Dis. 3, 1–12 (2017).

    Article 

    Google Scholar 

  • Prange, S. et al. Limbic stimulation drives mania in STN-DBS in Parkinson disease: a prospective study. Ann. Neurol. 92, 411–417 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Hristova, A. et al. Effect and time course of deep brain stimulation of the globus pallidus and subthalamus on motor features of Parkinson’s disease. Clin. Neuropharmacol. 23, 208–211 (2000).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Koeglsperger, T., Palleis, C., Hell, F., Mehrkens, J. H. & Bötzel, K. Deep brain stimulation programming for movement disorders: current concepts and evidence-based strategies. Front. Neurol. 10, 1–20 (2019).

    Article 

    Google Scholar 

  • Merk, T. et al. Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease. eLife 11, e75126 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ansó, J. et al. Concurrent stimulation and sensing in bi-directional brain interfaces: a multi-site translational experience. J. Neural Eng. 19, 026025 (2022).

    Article 

    Google Scholar 

  • Degenhart, A. D. et al. Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. J. Neural Eng. 13, 139–148 (2016).

    Article 

    Google Scholar 

  • Volkova, K., Lebedev, M. A., Kaplan, A. & Ossadtchi, A. Decoding movement from electrocorticographic activity: a review. Front. Neuroinform. 13, 00074 (2019).

    Article 

    Google Scholar 

  • Blakely, T., Miller, K. J., Zanos, S. P., Rao, R. P. N. & Ojemann, J. G. Robust, long-term control of an electrocorticographic brain-computer interface with fixed parameters. Neurosurg. Focus 27, 4–8 (2009).

    Article 

    Google Scholar 

  • Pels, E. G. M. et al. Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis. Clin. Neurophysiol. 130, 1798–1803 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Asaad, W. F. & Sheth, S. A. What’s the n? On sample size vs. subject number for brain-behavior neurophysiology and neuromodulation. Neuron 112, 2086–2090 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bundy, D. T., Pahwa, M., Szrama, N. & Leuthardt, E. C. Decoding three-dimensional reaching movements using electrocorticographic signals in humans. J. Neural Eng. 13, 026021 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Leuthardt, E. C., Schalk, G., Wolpaw, J. R., Ojemann, J. G. & Moran, D. W. A brain-computer interface using electrocorticographic signals in humans. J. Neural Eng. 1, 63–71 (2004).

    Article 
    PubMed 

    Google Scholar 

  • Athalye, V. R., Carmena, J. M. & Costa, R. M. Neural reinforcement: re-entering and refining neural dynamics leading to desirable outcomes. Curr. Opin. Neurobiol. 60, 145–154 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Cavallo, A. & Neumann, W. J. Dopaminergic reinforcement in the motor system: implications for Parkinson’s disease and deep brain stimulation. Eur. J. Neurosci. 59, 457–472 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Yttri, E. A. & Dudman, J. T. Opponent and bidirectional control of movement velocity in the basal ganglia. Nature 533, 402–406 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wu, M. C. K., David, S. V. & Gallant, J. L. Complete functional characterization of sensory neurons by system identification. Annu. Rev. Neurosci. 29, 477–505 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jackson, A., Mavoori, J. & Fetz, E. E. Correlations between the same motor cortex cells and arm muscles during a trained task, free behavior, and natural sleep in the macaque monkey. J. Neurophysiol. 97, 360–374 (2007).

    Article 
    PubMed 

    Google Scholar 

  • Wang, N. X. R., Olson, J. D., Ojemann, J. G., Rao, R. P. N. & Brunton, B. W. Unsupervised decoding of long-term, naturalistic human neural recordings with automated video and audio annotations. Front. Hum. Neurosci. 10, 00165 (2016).

    Article 

    Google Scholar 

  • Dixon, T. et al. Data from: Movement-responsive deep brain stimulation for Parkinson’s disease using a remotely optimized neural decoder. Dryad https://doi.org/10.5061/dryad.4xgxd25hw (2025).

  • Dixon, T. dixon-2025-move-adbs. GitHub https://github.com/Weill-Neurohub-OPTiMaL/dixon-2025-move-adbs (2025).

  • Dixon, T. rcssim. GitHub https://github.com/Weill-Neurohub-OPTiMaL/rcs-simulation (2025).



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